Winkelmand
Acetylcholine processing in a synapse. After release acetylcholine is broken down by the enzyme acetylcholinesterase.

What are Cholinergics?

When a supplement enhances the activity of acetylcholine, an important neurotransmitter linked to memory and attention span, it is said to be cholinergic. Cholinergics have been studied in the setting of Alzheimer’s disease; however, more research is needed to determine their impact on cognition in younger individuals.

What Cholinergic sources are there?

Choline Bitartrate, Alpha GPC and CDP Choline can provide the choline the brain needs to make extra acetylcholine. Choline Bitartrate is cheaper, but more needs to be taken to achieve the same effectiveness as the other 2. CDP Choline is also a source of Uridine, which can accelerate neuronal development.

What properties do Cholinergics have?

Choline is a vitamin-like macronutrient necessary for the proper functioning of the liver, muscles and, yes, the brain. Consider choline to be one of the brain’s fundamental building blocks for cognition, given its importance as a precursor to the following compounds:

Acetylcholine (ACh) is a neurotransmitter that promotes communication between neurons and at the neuromuscular junction.

Phosphatidylcholine (PC) is an important part of the cell membrane and a conditional reserve for choline for the synthesis of acetylcholine.

Choline is often used with Racetam Nootropics because these racetams activate the acetylcholine receptors, generating more acetylcholine.

Furthermore, the European Food Safety Authority (EFSA) has established that choline helps with proper fat metabolism and homocysteine metabolism. The European Food Safety Authority (EFSA) has also established a causal relationship for the maintenance of normal liver function.

What sources can also influence the cholinergic circuits?

In addition to the Choline sources Choline Bitartrate, Alpha GPC and CDP Choline, there are other Nootropic substances that affect cholinergic circuits through additional direct and indirect biomechanical pathways, most notably:

Bacopa Monnieri and Huperzine A can inhibit acetylcholinesterase, an enzyme that breaks down acetylcholine.

Phosphatidylserine is a phospholipid ingredient of the cholinergic pathway that plays an important role in the fluidity of brain cell membranes.

Despite several studies on nootropics, no health claim can and should not be made on the effect and properties of the products. Read the instructions before use!